期刊论文

中文

中医药导报

1672-951X

2020

26

14

13-16

10.13862/j.cnki.cn43-1446/r.2020.14.003

重点疑难疾病中西医临床协作试点项目(国中医药办医政发[2018]3号) 湖南省中医药科研计划项目(201516) 湖南省教育厅科学研究项目(16A158) 湖南中医药大学中医学国内一流建设学科(湘教通[2018]469号)。

本校为第一机构

目的:探讨心痛泰对动脉粥样硬化(AS)兔血清IL-1、TNF-α及主动脉髓过氧化物酶(MPO)表达的影响。方法:120只兔随机分为空白组、模型组、瑞舒伐他汀组、心痛泰高剂量组、心痛泰中剂量组和心痛泰低剂量组,每组20只。除空白组外,其余各组均采用高脂饲料喂养联合免疫损伤复制AS模型,在施以造模因素的同时,心痛泰高、中、低剂量组和瑞舒伐他汀组予以药物干预,空白组与模型组灌服同等体积的生理盐水,共8周。观察主动脉组织的病理形态学变化,并检测血清IL-1、TNF-α含量及主动脉MPO蛋白和MPO mRNA的表达量。结果:模型组兔血清IL-1、TNF-α含量及主动脉MPO蛋白及MPO mRNA的表达明显高于空白组(P

Objective:To investigate the effect of Xintongtai on the expression of serum IL-1,TNF-α and aortic myeloperoxidase(MPO)in atherosclerotic(AS)rabbits.Methods:A total of 120 rabbits were randomly divided into blank group,model group,rosuvastatin group,Xintongtai high-dose group,Xintongtai medium-dose group and Xintongtai low-dose group,with 20 rabbits in each group.Except for the blank group,all the other groups were fed with high-fat diet combined with immune injury to replicate the AS model.At the same time,Xintongtai high,medium and low-dose ...