期刊论文

Effect of Chaihu Sanshen Capsule(柴胡三参胶囊)on RyR2 mRNA Expression of Myocardial Cells in Rats with Ischemic Arrhythmia

中文

中医药导报

1672-951X

2020

26

10

32-35

10.13862/j.cnki.cn43-1446/r.2020.10.005

湖南省自然科学基金科卫联合项目(2018JJ6038) 湖南省中医药科研计划项目(201703) 湖南省学位与研究生教育改革研究项目(2019JGYB163) 湖南中医药大学中医学国内一流建设学科。

本校为第一机构

目的:探讨柴胡三参胶囊对缺血性心律失常大鼠心肌细胞兰尼碱受体(ryanodine receptors,RyR) mRNA表达的影响,为柴胡三参胶囊的临床应用提供实验依据。方法:60只Wistar大鼠随机分为假手术组、模型组、空白组、柴胡三参胶囊组、参松养心胶囊组、维拉帕米组,每组10只。相应干预10 d后,空白组不作任何处理,假手术组只开胸不结扎,其余各组采取大鼠左冠状动脉前降支高位结扎法制作心肌缺血性心律失常模型,再用PCR法检测RyR2 mRNA在各组大鼠心肌中的表达水平情况。结果:柴胡三参胶囊组大鼠心律失常评分低于模型组(P

Objective:To explore the effect of Chaihu Sanshen capsule on the expression of ryanodine receptors(RyR)2 in myocardial cells of ischemic arrhythmia rats,and to provide experimental basis for the clinical application of Chaihu Sanshen capsule.Methods:A total of 60 Wistar rats were randomly divided into sham operation group,model group,blank group,Chaihu Sanshen capsule group,Shensong Yangxin capsule group and verapamil group,10 rats in each group.After corresponding intervention for 10 days,the blank group was left without any treatment,the sham operation group only had thoracotomy without liga...