期刊论文

Study on the Mechanism of Compound Baqia(Smilacis Chinae Rhizoma)in the Treatment of Non-small Cell Lung Cancer Based on Network Pharmacology

中文

中医药导报

1672-951X

2023

29

08

132-139

10.13862/j.cn43-1446/r.2023.08.026

湖南省科技计划项目（2016SK2048）；

本校为第一机构

目的：通过网络药理学探究复方菝葜（FFBQ）治疗非小细胞肺癌（NSCLC）的潜在作用机制。方法：从《中华人民共和国药典》、中药系统药理学数据库与分析平台（TCMSP）、中国知网、PubChem中收集归纳FFBQ中8味药材的成分、归经及靶标信息；以口服生物利用度（OB）≥30%和类药性（DL）≥0.18为条件筛选FFBQ的潜在活性成分及靶标；通过OMIM、GeneCards、DisGeNET疾病数据库查询NSCLC相关靶标。利用STRING平台构建成分-疾病靶标的蛋白-蛋白互作网络；采用Cytoscape 3.7.1软件实现归经、药材-活性成分-靶标等多层次复杂网络关系的可视化。对经网络筛选获得的关键靶标，在DAVID平台进行基因本体（GO）注...

Objective:To explore the potential mechanism of Compound Baqia(Smilacis Chinae Rhizoma)(FFBQ)in the treatment of non-small cell lung cancer(NSCLC)through network pharmacology.Methods:The ingredients,meridians,and target information of 8 medicinal herbs in FFBQ were coll...MORE Objective:To explore the potential mechanism of Compound Baqia(Smilacis Chinae Rhizoma)(FFBQ)in the treatment of non-small cell lung cancer(NSCLC)through network pharmacology.Methods:The ingredients,meridians,and target information of 8 medicinal herbs in FFBQ were collec...