期刊论文

中文

中医药导报

1672-951X

2024

30

02

32-36+47

10.13862/j.cn43-1446/r.2024.02.006

20201181:湖南省卫生健康委科研课题 201519:湖南省中医药科研计划重点项目

本校为第一机构

目的：探究开玄泄浊方对阳虚型银屑病大鼠外周血辅助性T细胞17（Th17）/调节性T细胞（Treg）平衡及相关细胞因子表达的影响。方法：将72只大鼠随机分为空白对照组（16只）、模型组（56只）。所有大鼠背部脱毛后，空白对照组大鼠外涂凡士林，模型组大鼠予5%咪喹莫特乳膏外用+大黄灌胃建立阳虚型银屑病SD大鼠模型。将50只造模成功大鼠随机分为模型对照组、雷公藤多苷片组和开玄泄浊方低、中、高剂量组，每组10只。各组大鼠予以相应药物灌胃干预，1次/d，连续7 d。观察并记录大鼠背部皮损银屑病面积与严重性指数（PASI）评分，流式细胞仪检测外周血Th17/Treg比例，ELISA法检测白介素-17（IL-17）、...

Objective:To investigate the effect of Kaixuan Xiezhuo recipe on T helper cell 17(Th17)/regulatory T cells(Treg)balance and expression of related cytokines in peripheral blood of Yang deficiency psoriasis rats.Methods:Totally 72 rats were randomly divided into blank control group(n=16)and model group(n=56).After all the rats'backs were depilated,rats were externally coated with Vaseline in blank control group,while the rats in model group were given 5%imiquimod cream externally as well as Dahuang(rhubarb)gavage to establish the SD rat model of ...