期刊论文

Experimental Study on Guiyuan wine Sedative Hypnotic Action on Mice

中文

深圳中西医结合杂志

1007-0893

2016

26

20

6-8

10.16458/j.cnki.1007-0893.2016.20.003

湖南中医药大学中医诊断学国家重点学科开放基金项目资助课题（2014-27）；

本校为第一机构

目的:探讨桂圆酒对小鼠的镇静催眠作用。方法:选取清洁级昆明种雄性小鼠75只,随机均分为空白组、高粱酒白酒组、桂圆酒组、桂圆水煎液组、酸枣仁组,分别对各组小鼠按组名灌胃给药（空白组以蒸馏水20 mL/kg灌胃）,1次/d,连续10 d,末次给药后观察各药对小鼠自主活动的影响;观察药物协同戊巴比妥钠对小鼠入睡率、睡眠潜伏期、睡眠时间的影响。结果:桂圆酒、桂圆水煎液都能降低小鼠自主活动的次数,增加阈下剂量戊巴比妥钠下小鼠的入睡的只数,缩短睡眠潜伏期,延长睡眠时间,且桂圆酒的药效更加显著。结论:桂圆酒、桂圆水煎液都有镇静催眠作用,桂圆酒的药效更加显著。

Objective To investigate the sedative and hypnotic effects of Guiyuan wine on mice.Methods The mice were randomly divided into control group,wine group,Guiyuan wine group,Guiyuan decoction group and Suanzaoren group.Mice were gavaged 1 times a day for 10 days,after the end of the last administration to observe the effect of the drug on mice independent activities; Observation of drug synergism with sodium on the effects of sleep latency,sleep latency and sleep latency in mice.Result Guiyuan wine,Guiyuan decoction can inhibit the spontaneous activity of mice; and increase the number of mice to ...