Green functional carbon dots derived from herbal medicine ameliorate blood-brain barrier permeability following traumatic brain injury

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成果类型：

期刊论文

作者：

Luo, Weikang;Zhang, Lianglin;Li, Xuexuan;Zheng, Jun;Chen, Quan;...

作者机构：

[Wang, Yang; Zhang, Lianglin; Li, Xuexuan; Luo, Weikang; Wu, Yao; Yang, Zhaoyu; Cheng, Menghan; Tang, Tao; Chen, Quan; Chen, Yao] Cent South Univ, Xiangya Hosp, Dept Integrated Tradit Chinese & Western Med, Inst Integrat Med, Changsha 410008, Peoples R China.

[Wang, Yang; Zhang, Lianglin; Li, Xuexuan; Luo, Weikang; Wu, Yao; Yang, Zhaoyu; Cheng, Menghan; Tang, Tao; Chen, Quan; Chen, Yao] Cent South Univ, Xiangya Hosp, Lab Interdisciplinary Sci Tradit Chinese Med, Changsha 410008, Peoples R China.

[Wang, Yang; Zhang, Lianglin; Li, Xuexuan; Luo, Weikang; Wu, Yao; Yang, Zhaoyu; Cheng, Menghan; Tang, Tao; Chen, Quan; Chen, Yao] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Peoples R China.

[Zheng, Jun] Cent South Univ, Coll Chem & Chem Engn, Changsha 410083, Peoples R China.

[Zhang, Wei] Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Changsha 410208, Peoples R China.

语种：

英文

关键词：

carbon dots;traumatic brain injury;herbal medicine;blood-brain barrier;claudin 5

期刊：

纳米研究：英文版

ISSN：

1998-0124

年：

2022

卷：

期：

页码：

9274-9285

DOI：

10.1007/s12274-022-4616-8

基金类别：

National Natural Science Foundation of China [81973665]; Science and Technology Innovation Program of Hunan Province [2021RC3030]; Fundamental Research Funds for the Central Universities of Central South University [2021zzts1028]; InnovationDriven Project of Central South University [2020CX047]

机构署名：

本校为其他机构

院系归属：

中西医结合学院

摘要：

To repair the blood-brain barrier (BBB) after traumatic brain injury (TBI) remains a multidisciplinary challenge. No first-line drugs are available. Here, we reported a novel and non-toxic functional negative-charged carbon dots (CDs) generated from green Semen pruni persicae and Carthamus tinctorius L. (TH-CDs) through a hydrothermal synthesis without any organic solvent. The surface of TH-CDs retained part functional groups of active pharmacophores from both drugs. TH-CDs could improve the neurological function, brain edema, neuronal damage, and the BBB permeability by tail vein injection of...

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Green functional carbon dots derived from herbal medicine ameliorate blood-brain barrier permeability following traumatic brain injury

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