Chemical and biological study of aplysiatoxin derivatives showing inhibition of potassium channel Kv1.5

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成果类型：

期刊论文

作者：

Tang, Yang-Hua;Wu, Jing;Fan, Ting-Ting;Zhang, Hui-Hui;Gong, Xiao-Xia;...

作者机构：

[Tang, Yang-Hua; Fan, Ting-Ting; Zhang, Hui-Hui; Gong, Xiao-Xia; Han, Bing-Nan] Zhejiang Sci Tech Univ, Coll Life Sci & Med, Res Ctr Marine Biol & Nat Prod, Hangzhou 310018, Zhejiang, Peoples R China.

[Tang, Yang-Hua] Hunan Univ Chinese Med, Grad Sch, Dept Pharm, Changsha 410208, Hunan, Peoples R China.

[Wu, Jing; Zhang, Jian] Shanghai Jiao Tong Univ, Sch Med, Dept Pathophysiol, Shanghai 200025, Peoples R China.

[Lin, Hou-Wen] Shanghai Jiao Tong Univ, State Key Lab Oncogenes & Related Genes, Res Ctr Marine Drugs, Dept Pharm,Ren Ji Hosp,Sch Med, Shanghai 200127, Peoples R China.

[Cao, Zheng-Yu] China Pharmaceut Univ, Jiangsu Prov Key Lab TCM Evaluat & Translat Dev, Nanjing, Jiangsu, Peoples R China.

语种：

英文

期刊：

RSC Advances

ISSN：

2046-2069

年：

2019

卷：

期：

页码：

7594-7600

DOI：

10.1039/C9RA00965E

基金类别：

Special Fund for Agro-scientific Research in the Public Interest ofZhejiang province [LGN18C190011]; National Natural Science Foundation ofChinaNational Natural Science Foundation of China [81373321, U1605221];Science Foundation of Zhejiang Sci-Tech University [17042058-Y]; Projectfor Jiaozhou Excellent Innovation Team [18-CX-1]; National Key Researchand Development Program of China [2016YFF0202300, 2018YFC0310900]

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本校为其他机构

院系归属：

药学院

研究生院

摘要：

Three new aplysiatoxins, neo-debromoaplysiatoxin D (1), oscillatoxin E (2) and oscillatoxin F (3), accompanied by four known analogues (4-7), were identified from the marine cyanobacterium Lyngbya sp. Structural frames differ amongst these metabolites, and therefore we classified compounds 1 and 4-6 as aplysiatoxins as they possess 6/12/6 and 6/10/6 tricyclic ring systems featuring a macrolactone ring, and compounds 2, 3 and 7 as oscillatoxins that feature a hexane-tetrahydropyran in a spirobicyclic system. Bioactivity experiments showed that compounds 1 and 4-6 presented significant expressio...

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Chemical and biological study of aplysiatoxin derivatives showing inhibition of potassium channel Kv1.5

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