期刊论文

Developing an integrated model of toxicity and efficacy of Chinese medicine based on supramolecular “imprinting template” analysis

中文

药学学报

0513-4870

2018

53

11

1808-1816

10.16438/j.0513-4870.2018-0532

国家自然科学基金资助项目（81573691,81703824,81503492） 湖南省自然科学基金资助项目（2017JJ3236,2016JJ4065） 湖南省教育厅基金（17B200） 湖南省药学重点学科 中药成药性与制剂制备湖南省重点实验室（2016TP1017） 湖湘中药资源保护与利用2011协同创新中心等项目平台资助 国家留学基金资助.

本校为第一机构

中药是中医治病的物质基础,既遵循中医基础理论指导,也遵循药物作用普遍规律,毒与效并存。其毒与效的整合规律彰显于方剂学中,以"七情"和"阴阳"和合的配伍经验定性表征。当按中医药理论遣方口服用药仍产生毒性,或传统中药给药方式被打破,其靠经验来维系的中药毒与效的整合规律就显得束手无策,特别是近年来随着中药现代化和中药新药创制不断推进,中药安全性事件频发,建立一套适用多成分中药的毒与效的整合方法非常迫切。随着生物超分子化学不断与中医药基础理论结合,一种基于中药超分子"印迹模板"毒与效的整合模式初见端倪。中药与人体都是生物超分子体,应遵循超分子"印迹模板"自主作用规律,其所...

Chinese material medica (CMM) is the foundation for treating disease using traditional Chinese medicine (TCM), which is not only guided by the basic theory of TCM but also follows the general rules of drug action. There are both toxicity and efficacy in TCM. For TCM the integrated regularities of its toxicity and efficacy were demonstrated in their prescription, which were qualitatively characterized by compatible experiences such as "seven emotions", "Yin" and "Yang" compatibility, etc. When the toxicity is still produced by oral administratio...