期刊论文

Advance in relationship between receptor gene abnormality and depression

中文

药学学报

0513-4870

2020

55

03

384-391

10.16438/j.0513-4870.2019-0600

81773924:国家自然科学基金 81573636:国家自然科学基金 7182114:北京市自然科学基金

本校为第一机构

抑郁症是一种以心境低落、悲观厌世、认知和睡眠障碍为主要特征的慢性综合征,临床上具有高发病率、高自杀率和低就诊率、低治疗率的特点。抑郁症发病40%~50%的风险来自基因。因此,研究基因异常是研究抑郁症发病内在原因的重要部分,其中受体基因异常是导致抑郁症发病的重要因素。研究潜在的受体基因位点有望成为未来抑郁症治疗的新靶点,能够为抑郁症的早期诊断、预防和治疗提供理论依据。

Depression,a chronic syndrome with low mood,pessimism,cognitive and sleep disorders,is characterized by high incidence,high suicide rate,low consultation and treatment rate.40%-50% of the risk of depression comes from genes,so studying on gene abnormalities serves as an important part of the research in the internal causes of depression,among which the receptor gene abnormalities are crucial factors.The study of potential receptor gene loci is expected to be new target for the treatment of depression in the future,which can provide theoretical...