Cisplatin is one of the most commonly used chemotherapeutic drugs in clinic and has good therapeutic effect on various cancers, but the development of drug resistance limits its clinical treatment. The development of cisplatin resistance is caused by many factors, including the decrease of intracellular cisplatin accumulation, the inactivation of cisplatin by mercaptan proteins, the increase of DNA damage repair, apoptosis inhibition, tumor microenvironment and cancer stem cells. In recent years, traditional Chinese medicine (TCM) has been favored for its remarkable effect of reversing cisplat...
