Flagellar Hooks and Hook Protein FlgE Participate in Host Microbe Interactions at Immunological Level

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成果类型：

期刊论文

作者：

Shen, Ying;Chen, Lin;Wang, Meixiang;Lin, Dandan;Liang, Zhongjie;...

通讯作者：

Wang, Yiqiang;Zhao, Ge

作者机构：

[Wang, Yiqiang; Shen, Ying] Soochow Univ, Affiliated Hosp 1, Jiangsu Inst Hematol,Thrombosis & Hemostasis Grp, Collaborat Innovat Ctr Hematol,MOH Key Lab Thromb, Suzhou 215007, Peoples R China.

[Duan, Kangmin; Chen, Lin] Univ Manitoba, Fac Hlth Sci, Dept Oral Biol & Med Microbiol, Winnipeg, MB R3E 0W2, Canada.

[Chen, Lin; Song, Peiqing] Northwest Univ, Mol Microbiol Lab, Xian 710069, Peoples R China.

[Tang, Hua; Wang, Meixiang] Taishan Med Univ, Inst Immunol, Tai An 271000, Shandong, Peoples R China.

[Yuan, Qing; Wang, Yiqiang; Lin, Dandan] Shandong Eye Inst, Shandong Prov Key Lab Ophthalmol, Qingdao 266071, Peoples R China.

通讯机构：

[Wang, Yiqiang] S

[Zhao, Ge] C

Soochow Univ, Affiliated Hosp 1, Jiangsu Inst Hematol,Thrombosis & Hemostasis Grp, Collaborat Innovat Ctr Hematol,MOH Key Lab Thromb, Suzhou 215007, Peoples R China.

Shandong Eye Inst, Shandong Prov Key Lab Ophthalmol, Qingdao 266071, Peoples R China.

China Anim Hlth & Epidemiol Ctr, Qingdao 266114, Peoples R China.

语种：

英文

期刊：

Scientific Reports

ISSN：

2045-2322

年：

2017

卷：

期：

页码：

1433

DOI：

10.1038/s41598-017-01619-1

基金类别：

National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81271050, 81571544]; Jiangsu Provincial Special Program of Medical Science, Jiangsu Province's Key Medical Center [BL2012005]; Soochow University

机构署名：

本校为其他机构

院系归属：

中医学院

摘要：

Host-microbe interactions determine the outcome of host responses to commensal and pathogenic microbes. Previously, two epithelial cell-binding peptides were found to be homologues of two sites (B, aa168-174; F, aa303-309) in the flagellar hook protein FlgE of Pseudomonas aeruginosa. Tertiary modeling predicted these sites at the interface of neighboring FlgE monomers in the fully formed hook. Recombinant FlgE protein stimulated proinflammatory cytokine production in a human cell line and in murine lung organoid culture as detected with real-time RT-PCR and ELISA assays. When administered to m...

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Flagellar Hooks and Hook Protein FlgE Participate in Host Microbe Interactions at Immunological Level

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