期刊论文

The effects of Panax notoginseng saponins on the damage of hippocampus CA1 following cerebral ischemia-reperfusion in rats

中文

湖南中医药大学学报

1674-070X

2004

24

4

4-6

10.3969/j.issn.1674-070X.2004.04.002

湖南省科委发展项目 （ 0 1ssy2 0 0 8—2 6）；

本校为第一机构

目的探讨大鼠脑缺血再灌注后海马CA1区神经元损伤的病理改变及三七总皂苷(PNS)对其的影响.方法采用线栓法制备大鼠左侧大脑中动脉阻断(MCAO)局灶性脑缺血模型,缺血2 h,再灌注46h.大鼠随机分为假手术组、缺血再灌模型组、PNSⅠ组和PNSⅡ组.以神经症状缺损记分、海马CA1区组织学分级、海马CA1区神经元密度等作为评价指标.结果三七总皂苷组神经症状明显减轻或接近正常,其行为评分得分明显低;三七总皂苷组海马CA1区组织学分级降低、神经元密度增加,与模型组间有显著性差异.结论三七总皂苷能减轻脑缺血再灌注引起的损伤性神经症状及海马CA1区神经元损伤的程度.

Objective To investigate the pathological changes of neurons in hippocampus CA1 following cerebral ischemia-reperfusion in rats and the effects of Panax notoginseng saponins (PNS) on this kind of damage.Methods The model of local cerebral ischemia-reperfusion was prepared by the intravascular theread-occlusing procedures to cause 2 hours of occlusion and followed by 46 hours of reperfusion in rats.The animals were randomly divided into 4 groups, i.e.sham operation group (SOG), modeling group (MG),treating group 1 with PNS (TG1) and treating group 2 (TG2), also treated with PNS at different dos...