Genome-wide CRISPR-Cas9 viability screen reveals genes involved in TNF-alpha-induced apoptosis of human umbilical vein endothelial cells

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Cai, Meng;Li, Sitao;Shuai, Yunfei;Li, Jie;Tan, Jieqiong*;...

通讯作者：

Zeng, Qiyi;Tan, Jieqiong

作者机构：

[Zeng, Qiyi; Cai, Meng] Southern Med Univ, Zhujiang Hosp, Dept Pediat, Guangzhou 510280, Guangdong, Peoples R China.

[Li, Sitao] Sun Yat Sen Univ, Affiliated Hosp 6, Dept Pediat, Guangzhou, Guangdong, Peoples R China.

[Shuai, Yunfei] Hunan Univ Chinese Med, Affiliated Hosp 1, Dept Pediat, Changsha, Hunan, Peoples R China.

[Li, Jie; Tan, Jieqiong] Cent S Univ, Ctr Med Genet, Changsha 410078, Hunan, Peoples R China.

[Li, Jie; Tan, Jieqiong] Cent S Univ, Sch Life Sci, Changsha 410078, Hunan, Peoples R China.

通讯机构：

[Zeng, Qiyi] S

[Tan, Jieqiong] C

Southern Med Univ, Zhujiang Hosp, Dept Pediat, Guangzhou 510280, Guangdong, Peoples R China.

Cent S Univ, Ctr Med Genet, Changsha 410078, Hunan, Peoples R China.

Cent S Univ, Sch Life Sci, Changsha 410078, Hunan, Peoples R China.

语种：

英文

关键词：

apoptosis;CRISPR-Cas9;NLRX1;sepsis;TNF-α

期刊：

Journal of Cellular Physiology

ISSN：

0021-9541

年：

2019

卷：

234

期：

页码：

9184-9193

DOI：

10.1002/jcp.27595

机构署名：

本校为其他机构

院系归属：

第一中医临床学院

摘要：

Tumor necrosis factor alpha (TNF-alpha), a pivotal cytokine in sepsis, protects the host against pathogens by promoting an inflammatory response while simultaneously inducing apoptosis of the vascular endothelium. Unfortunately, inhibitors targeting certain components of the TNF-alpha signaling pathway to reduce cellular apoptosis have failed to translate into clinical applications, partly due to the adverse effects of excessive immunosuppression. In an attempt to discover potential targets in the TNF-alpha signaling pathway to modulate moderate inflammation and apoptosis during the developmen...

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Genome-wide CRISPR-Cas9 viability screen reveals genes involved in TNF-alpha-induced apoptosis of human umbilical vein endothelial cells

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