期刊论文

Effects of ultra-micro powder Qiweibaizhusan on metabolism diversity of intestinal microflora in diarrhea mice with dysbacteriosis

Tan, Z.

中文

应用与环境生物学报

Chinese Journal of Applied and Environmental Biology

1006-687X

2014

20

1

93-100

10.3724/SP.J.1145.2014.00093

国家自然科学基金项目(81173214);the National Natural Science Foundation of China(81173214)

本校为第一机构

为探讨超微七味白术散对菌群失调腹泻疗效的微生态学机理，采用灌胃头孢拉定和硫酸庆大霉素混合抗生素进行小鼠菌群失调腹泻造模，灌胃给药七味白术散传统汤药和1／2剂量超微汤药进行治疗，正常组和模型组灌胃等量的无菌水，3d后，提取肠道微生物，在有氧条件下，运用Biolog微生物自动分析系统研究肠道微生物的代谢情况．结果显示，培养72h时，各组的颜色平均变化率（AWCD）趋于稳定，且正常组〉1／2剂量的超微汤药治疗组〉传统汤药治疗组〉模型组；正常组的Shannon指数、Shannon均匀度、Simpson指数和McIntosh指数等微生物群落多样性指数均为最大，且与其他各组都存在极显著性差异（P〈0．01）...

To study the microecological mechanism for ultra-micro Qiweibaizhusan on diarrhea with intestinal dysbacteriosis, the mice were modeled dysbacteriosis by stomach injection of mixed cefradine and gentamycin sulfate. Then the mice in one treatment group were given the traditional decoction of Qiweibaizhusan; those in the other treatment group were given 1/2 dose of ultra-micro powder of Qiweibaishusan; and those in the normal group and model group were given steriled water, all through intragastric administration. After three days the intestinal microflora were extracted, and their metabolism we...