期刊论文

Effects of Jiangzhiligan Decoction on intestinal microbiota and enzyme activities of rats with non-alcoholic fatty liver disease induced by high-fat diet

Tan, Z.

中文

应用与环境生物学报

1006-687X

2016

22

3

442-445

10.3724/SP.J.1145.2015.11001

(81573951):国家自然科学基金项目 (81573951):Supported by the National Natural Science Foundation of China

本校为第一且通讯机构

为了解降脂理肝汤对非酒精性脂肪肝病(NAFLD)大鼠肠道微生物及其酶活性的影响,建立高脂饮食诱导的NAFLD大鼠模型,以降脂理肝汤治疗4周后,分析比较体重、肝重、肝指数、肠道菌群数和酶活.结果显示,模型组大鼠体重、肝重和肝指数明显高于正常组(P < 0.01),肠道细菌总数、大肠杆菌和乳酸菌数量明显多于正常组(P < 0.05),肠道木聚糖酶、淀粉酶和蛋白酶活性高于正常组(P < 0.05);降脂理肝汤显著降低NAFLD大鼠体重、肝重和肝指数(P < 0.05),并且能抑制肠道细菌的生长,抑制大肠杆菌和乳酸菌的生长(P < 0.05),使细菌总数和乳酸菌数量恢复至正常组水平(P > 0.05).此外,降脂理肝汤还能抑制NAFLD大鼠肠道木...

Objectives: This research aimed to provide scientific basis for clinical use of jiangzhiligan decoction (JZLGT) by exploring its effect on intestinal microbiota and enzyme activities of rats with non-alcoholic fatty liver disease (NAFLD). Methods: The NAFLD model was duplicated with high-fat diet in rats, and then the modeled rat were treated with JZLGT for four weeks, the body weight, liver weight, liver index, intestinal microbiota and enzyme activities were determined . Results: The results showed that the body weight, liver weight and liver index in the model group were increased than thos...