Xiaoyaosan improves depressive-like behaviors by regulating the NLRP3 signaling pathway in the rat cerebral cortex

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成果类型：

期刊论文

作者：

Cong Chen;Rong Yu;Zhe Xue;Zhiyi Yan;Qinlai Bian;...

通讯作者：

Jiaxu Chen

作者机构：

School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China

School of Basic Medicine, Guizhou University of Chinese Medicine, Guiyang, 550025, China

School of Graduate Students, Hunan University of Traditional Chinese Medicine, Changsha, 410208, China

School of Traditional Chinese Medicine, Jinan University, Guangzhou, 510632, China

[Yunzhi Chen] 基础医学院

通讯机构：

[Jiaxu Chen] S

School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China<&wdkj&>School of Traditional Chinese Medicine, Jinan University, Guangzhou, 510632, China

语种：

英文

关键词：

antidepressant agent;beta actin;Chinese medicinal formula;cryopyrin;fluoxetine;interleukin 1beta;interleukin 1beta converting enzyme;mcc 950;messenger RNA;unclassified drug;xiaoyaosan;adult;animal experiment;animal model;animal tissue;Article;behavior change;body mass;body weight;brain cortex;controlled study;depression;fluid intake;immobilization stress;male;mRNA expression level;nonhuman;open field test;protein expression;rat;real time polymerase chain reaction;regulatory mechanism;signal transduction;sucrose preference test;time to treatment;Western blotting

期刊：

中医科学杂志(英文)

ISSN：

2095-7548

年：

2020

卷：

期：

页码：

265-273

DOI：

10.1016/j.jtcms.2020.08.001

基金类别：

Funding was provided by the Program of Science and Technology Department of Guizhou Province [Nos. (2016)1012 ], the Program of Education Department of Guizhou Province [Nos. (2016)191 ], and the National Natural Science Foundation of China (Nos. 81630104 , 81573956 , and 81860818 ).

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摘要：

Objective: To observe changes in the molecular expression of the NLR Family Pyrin Domain Containing Protein 3 (NLRP3) pathway in depressed rats after treatment with Xiaoyaosan, and identify the regulatory mechanism of this compound. Methods: Male Sprague–Dawley rats were randomly divided into five groups with 12 rats in each group, including the control group, model group, Fluoxetine group, Xiaoyaosan group, and MCC950 group. A depression model was generated by chronic immobilization stress (induced by 3 h of restraint immobilization every day...

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Xiaoyaosan improves depressive-like behaviors by regulating the NLRP3 signaling pathway in the rat cerebral cortex

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