Transcriptional Reactivation of OTX2, RX1 and SIX3 during Reprogramming Contributes to the Generation of RPE Cells from Human iPSCs

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成果类型：

期刊论文

作者：

Li, Peng;Sun, Xiaofeng（孙晓峰）;Ma, Zhizhong;Liu, Yinan;Jin, Ying;...

通讯作者：

Shen, Li;Li, Tao

作者机构：

[Han, Shuo; Shen, Li; Zhang, Mingzhi; Li, Ruizhi; Sun, Haojie; Liu, Yinan; Li, Peng] Peking Univ, Stem Cell Res Ctr, Dept Cell Biol, Sch Basic Med Sci, Beijing 100191, Peoples R China.

[Sun, Xiaofeng] Hunan Univ Chinese Med, Dept Histol & Embryol, Inst Chinese Med, Sci Garden Dist Hanpu, Changsha 410208, Hunan, Peoples R China.

[Ma, Zhizhong; Jin, Ying] Peking Univ, Hosp 3, Ctr Eye, Beijing 100191, Peoples R China.

[Ge, Ruimin] Lund Univ, Univ Hosp, Lund Stem Cell Ctr, S-22242 Lund, Sweden.

[Ma, Yanling; Hao, Limin] Beijing Cellonis Biotechnol Co Ltd, Zhongguancun Biomed Pk, Beijing 100191, Peoples R China.

通讯机构：

[Shen, Li] P

[Li, Tao] Z

Peking Univ, Stem Cell Res Ctr, Dept Cell Biol, Sch Basic Med Sci, Beijing 100191, Peoples R China.

Zhejiang Normal Univ, Coll Chem & Life Sci, Dept Biol, Jinhua 321004, Zhejiang, Peoples R China.

语种：

英文

关键词：

epigenetic modification;induced pluripotent stem cells;reprogramming;retinal pigment epithelium

期刊：

International Journal of Biological Sciences

ISSN：

1449-2288

年：

2016

卷：

期：

页码：

505-517

DOI：

10.7150/ijbs.14212

基金类别：

National Basic Research Program of China (973 program)National Basic Research Program of China [2011CB510200]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81303004, 31470082]; Public Innovation Program [LY14C120001, 2014C37126]; Zhejiang Provincial Natural Science FoundationNatural Science Foundation of Zhejiang Province

机构署名：

本校为其他机构

院系归属：

中医学院

摘要：

Directed differentiation of human induced pluripotent stem cells (iPSCs) into retinal pigmented epithelium (RPE) holds great promise in cell replacement therapy for patients suffering from degenerative eye diseases, including age-related macular degeneration (AMD). In this study, we generated iPSCs from human dermal fibroblasts (HDFs) by electroporation with episomal plasmid vectors encoding OCT4, SOX2, KLF4, L-MYC together with p53 suppression. Intriguingly, cell reprogramming resulted in a metastable transcriptional activation and selective d...

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Transcriptional Reactivation of OTX2, RX1 and SIX3 during Reprogramming Contributes to the Generation of RPE Cells from Human iPSCs

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