Science and Technology Program of Guangzhou [202103030004]; Science and Technology Program of Guangzhou, China [82374306]; National Natural Science Foundation of China [2023JJ30456]; Natural Science Foundation of Hunan Province [2023A1515011221]; Guangdong Basic and Applied Basic Research Foundation
机构署名：
本校为其他机构
院系归属：
中医学院
摘要：
Inadequate antigen capture and insufficient antigen-presenting cell (APC) activity at tumor sites limit the effectiveness of in situ vaccines. To address this, poly(glutamic acid-cholinephosphate) (pGluCP) is introduced as a polymer with cell membrane adhesion properties capable of capturing both water-soluble and insoluble membrane antigens from necrotic tumor cells while recruiting more APCs. The approach uses manganese-mineralized black phosphorus (MnBP) coated with pGluCP and αPD-1 antibodies to create the MnBP@pGluCP-αPD-1 complex for in...
