期刊论文

Zhou, X.J.

中文

中国中西医结合杂志

1003-5370

2001

21

3

209-212

10.3321/j.issn:1003-5370.2001.03.016

国家中医药管理局资助课题! （No .97Y0 2 0 ）；

本校为第一机构

目的：研究寒证及热证豚鼠变应性鼻炎(AR)细胞功能和形态学特征。方法：以寒性、热性中药分别给予豚鼠造成寒证、热证模型，然后以甲苯二异氰酸酯和盐酸萘甲唑啉点鼻，分别造成AR和鼻炎模型，观察其细胞功能、数量及电镜下超微形态学特点。结果：AR模型豚鼠血嗜碱性粒细胞(BC)脱颗粒指数高于鼻炎模型豚鼠；其中寒证AR豚鼠又高于热证AR豚鼠(P＜0.05)。寒证AR豚鼠鼻粘膜肥大细胞(MC)及嗜酸性粒细胞(EC)数量多，浸润广泛，颗粒包膜不清，密度不均，颗粒内见空泡、融合及管道；而热证AR豚鼠及对照组豚鼠MC及EC数量少，无浸润，颗粒包膜清，密度均一，无颗粒空泡、融合及管道。结论：寒证AR豚鼠BC、M...

OBJECTIVE: To investigate the functional and morphological characteristics of cells in allergic rhinitis (AR) guinea-pigs with Cold or Heat Syndrome. METHODS: The Cold Syndrome or Heat Syndrome guinea-pig model was made, and then reformed into AR model or rhinitis medicamentosa (RM) model by using nose drops of 10% toluene di-isocyanate (TDI) or 0.1% naphazoline hydrochloride. The cell function, count and ultramicroscopic morphology characteristics in the model animals were observed. RESULTS: The degranulation index (DI), of blood basophils and the count of mast cells (MC) in nasal mucosa were...