期刊论文

中文

中国中西医结合杂志

1003-5370

2004

S1

219-221

本校为第一机构

目的研究中成药鼻敏片对豚鼠变应性鼻炎动物模型的影响。方法将60只豚鼠随机分为6组,即正常、模型、对照、治疗（鼻敏片分高、中、低剂量各1组）,每组各10只,以二异氰酸甲苯酯（TDI）为致敏源,对豚鼠行鼻内给药法建立鼻超敏反应动物模型,以息斯敏为对照,以豚鼠鼻分泌物涂片的细胞学检查、鼻甲粘膜组胺含量及血浆 P 物质为指标,探讨鼻敏片的作用和机理。结果模型组鼻分泌物中嗜酸性细胞、肥大细胞组胺及血浆 P 物质含量高于正常组,鼻敏片中、高剂量组均能有效降低上述指标,息斯敏组对相关指标影响不明显,鼻敏片低剂量组对血浆 P 物质含量影响不明显。结论鼻敏片通过阻断变应性鼻炎发病的多个环节...

Objective To study the effect of Bimin tablet(BMT),a TCM patent medicine,on the animal model of Guinea pigs with allergic rhinitis.Methods Sixty Guinea pigs were randomly divided into six groups,i.e.normal,model,control, high-dose,middle-dose and low-dose of BMT treated group,10 in each.Nasal hypersensitivity model was set up by instill- ing toluene 2,4 diisocyanate(TDI)as the sensitizer.Astemizole tablet was used as the control.Cytological examinatio...