期刊论文

中文

中国中西医结合杂志

1003-5370

2011

31

9

1254-1258

国家自然科学基金资助项目（No.30973759） 湖南省自然科学基金资助项目（No.09JJ3054）

本校为第一机构

目的 观察知柏地黄汤对解脲支原体(UU)感染大鼠生精细胞凋亡及对细胞凋亡线粒体调控效应因子Caspase-3、Caspase-9表达的影响.方法 从60只雄性SD大鼠中随机抽取45只,经膀胱注射造成UU感染动物模型,剩余15只作为假手术组.UU感染模型动物再随机分成模型组、美满霉素治疗组和知柏地黄汤治疗组,于接种后10d开始经灌胃给药,模型组和假手术组予生理盐水灌胃,美满霉素治疗组和知柏地黄汤治疗组分别予相应药物灌胃,连续灌胃21天后处死动物,检测各组生精细胞凋亡率、Caspase-3与Caspase-9表达水平和生精细胞超微结构改变.结果 与模型组比较,假手术组、美满霉素治疗组和知柏地黄汤治疗组在UU培养阳性率、生...

Objective To observe the effects of Zhibai Dihuang Decotion（ZDD） on the ureaplasma urealyticum（UU）-infected rats＇ spermatogenic cell apoptosis and expressions of Caspase-3 and Caspase-9.Methods 45 out of 60 male SD rats were randomly selected and made into the UU infected animal model.The rest 15 were taken as the sham-operation group.The UU infected model animals were then randomly divided into the model group,the minocycline group,and the ZDD group.From the 10th day after inoculation,normal saline was given to rats of the model group and...