期刊论文

He, F.

中文

中国中西医结合杂志

1003-5370

2011

31

11

1491-1495

湖南省科技厅科技计划资助项目（No.2007FJ40）； 湖南省自然科学基金资助项目（No.09JJ6042）； 国家中医药管理局中医药科学技术研究专项资助项目（No.06-07JB17）；

本校为第一机构

目的观察慢性乙肝病毒(hepatitis B virus, HBV)感染不同免疫状态肝郁脾虚证和肝胆湿热证患者外周血树突状细胞(dendritic cells, DCs)的功能变化，了解慢性HBV感染两证型的免疫表达特点，为中医辨证提供客观化依据。方法选取40例慢性HBV感染患者，根据免疫状态分为两组，慢性乙型肝炎组 （免疫清除状态）20例，其中肝郁脾虚证10例，肝胆湿热证10例；慢性HBV携带组（免疫耐受状态）20例，其中肝郁脾虚证10例，肝胆湿热证10例；另选取湖南中医药大学研究生志愿者体检健康者10名为健康对照组，分别对其外周血单个核细胞(peripheral blood mononuclear cells,PBMCs)进行体外培养，以倒置显微镜和电...

OBJECTIVE: To observe the functions of peripheral dendritic cells (DCs) in chronic hepatitis B virus (HBV) infection patients of Gan-depression Pi-deficiency syndrome (GPS) and Gan-Dan damp-heat syndrome (GDS) under different immune states, thus to study the features of the immune expressions of the two syndromes in chronic HBV infection, providing objective evidence for Chinese medicine syndrome typing. METHODS: The 40 chronic HBV patients were randomly assigned to two groups according to the immune state. Of them, there were 20 chronic HBV patients (under the condition of immune clearance; c...