期刊论文

Zhou, X.

中文

中国中西医结合杂志

1003-5370

2011

31

4

542-546

湖南省教育厅重点青年课题（No.08B057） 湖南省研究生科研创新项目（No.CX2009B173）

本校为第一机构

目的观察天蚕壮阳散对中老年男性雄激素部分缺乏综合征(partial androgen deficiency of agingmale,PADAM)模型大鼠睾丸间质细胞中类固醇合成快速调节蛋白(steroidogenic acute regulatory protein,stAR蛋白)表达的影响.方法以环磷酰胺造成生殖系统受损,雄激素部分缺乏的PADAM大鼠模型,按照随机分组的原则分为4组:正常对照组,模型组,丙酸睾酮组,天蚕壮阳散组,观察各组大鼠一般情况,体重,悬尾实验和强迫游泳实验,睾丸指数等改变以评价大鼠自身状况,放射免疫法测定各组治疗前后血清总睾酮(total testosterone,TT),游离睾酮(free testosterone,FT)水平,免疫组化法测定各组大鼠睾丸间质细胞stAR蛋白...

OBJECTIVE: To observe the effect of Tiancan Zhuangyang Powder (TCZYP) on the steroidogenic acute regulatory protein (stAR protein) expression of Leydig cells in model rats with partial androgen deficiency of aging male (PADAM). METHODS: PADAM rat model was prepared by cyclophosphamide induced reproductive system damage. Rats were randomly divided into four groups, i. e. the normal control group, the model group, the testosterone propionate group, and the TCZYP group. The general condition, body weight, tail suspension experiment and exhaustion swimming test, and the testicular index, etc. were...