期刊论文

中文

中国中西医结合杂志

1003-5370

2015

35

3

333-337

10.7661/CJIM.2015.03.0333

本校为第一机构

目的探讨益心泰颗粒对慢性心力衰竭兔肾髓质AQP_2蛋白及mRNA的影响。方法采用阿霉素耳缘静脉注射建立慢性心衰兔模型,将造模成功的家兔分为模型组、益心泰低(2.1 g/kg)、中(4.2 g/kg)、高剂量(8.4 g/kg)组和呋塞米组(2 mg/kg),另设正常对照组;模型组和正常对照组灌胃同等体积的生理盐水,1次/天,共干预4周。观察尿量、观察肾髓质病理形态学变化,并检测肾髓质AQP_2 mR-NA及其蛋白表达量。结果与正常对照组比较,模型组尿量减少(P

OBJECTIVE: To explore the effect of Yixintai Granule (YG) on mRNA and protein expression levels of AQP2 in renal medulla of chronic heart failure (CHF) rabbits. METHODS: CHF rat model was established by ear marginal vein injection of adriamycin. Successfully modeled rabbits were divided into the model group, the high (8.4 g/kg), middle (4.2 g/kg), and low dose (2.1 g/kg) YG group, and the Furosemide group (2 mg/kg). Besides, a normal control group was set up. Equal volume of physiological saline was administered to rabbits of the model group and the normal control group by gastrogavage. YG at ...