期刊论文

Effects of Effective Fractions ofPanax Notoginseng on the Expression of TF and TFPI-2 in Rat Endometrium with Whole Cycle Exogenous Estrogen Intervention

中文

中国中西医结合杂志

1003-5370

2017

37

2

215-219

10.7661/CJIM.2017.02.0215

国家自然科学基金项目（No.30271633） 陕西中医药大学自然科学培育基金（No.2015PY15）

本校为第一机构

目的探讨三七皂苷、三七黄酮、三七氨酸及其混合物对全周期持续外源性雌激素干预下的未成年大鼠子宫内膜组织因子(TF) 、组织因子途径抑制物2(TFPI-2)表达的影响。方法将160只雌性未成年大鼠随机分成空白组(40只)和模型组(120只),空白组给予生理盐水灌胃3周,模型组给予戊酸雌二醇悬液灌胃3周。在全周期(3周)干预后,将无性周期大鼠随机分成6组,即模型组、连续雌激素组、三七皂苷组、三七黄酮组、三七氨酸组、三七有效部位混合组。并分别给予生理盐水、雌激素、三七皂苷、三七黄酮、三七氨酸、三七有效部位混合物,连续灌胃2周。2周后检测子宫内膜中TF、TFPI-2及TF、TFPI-2 mRNA表达的水平。结果与...

Objective To observe the effects of notoginsenoside,Panax notoginseng flavonoids(PNF),Panax notoginseng acid (PNA),and their mixtures on the expressions of tissue factor (TF) and tissue factor pathway inhibitor 2 (TFPI-2) in rat endometriaum with whole cycle exogenous estrogen intervention. Methods Totally 160 female impuberty rats were randomly divided into the blank group (n = 40) and the model group (n = 120). Rats in the blank group were administered with normal saline by gastrogavage for 3 weeks,while those in the model group were administered with estradiol valerate suspension. The two i...