期刊论文

Effect of Shuyu Pill Combinined Longxuejie Capsules on Wound Healing in MKR Type 2 Diabetic Mice

中文

中国中西医结合杂志

1003-5370

2019

39

9

1110-1115

10.7661/j.cjim.20190729.084

湖南省大学生研究性学习和创新性实验项目(No.2014-204) 湖南省教育厅项目(No.16C1231).

本校为第一机构

目的通过薯蓣丸联合龙血竭胶囊对MKR转基因2型糖尿病小鼠创面进行干预,探讨薯蓣丸联合龙血竭胶囊对糖尿病创面愈合的影响。方法选取8周龄MKR小鼠80只,雌雄各半,按照小鼠的空腹血糖情况及体重随机分为5组:模型组、薯蓣丸+龙血竭组[薯蓣丸提取液(37.2 g/kg·d) ]、薯蓣丸组、龙血竭组、二甲双胍组,每组16只小鼠。另设16只C57/BL6小鼠作为正常组。制造全层皮肤缺损的创面模型后分别给药14天,观察空腹血糖、创面愈合率、病理形态结构、晚期糖基化终末产物(AGE)及T细胞亚群(CD3~+、CD4~+、CD8~+、CD4~+/CD8~+)含量。结果与模型组比较,给药14天时薯蓣丸+龙血竭组、薯蓣丸组、二甲双胍组空腹血糖降低(P...

Objective To investigate the effect of Shuyu Pill and Longxuejie Capsules on wound healing in MKR type 2 diabetic mice. Methods Eighty MKR mice,including 40 males and 40 females,were recruited at 8 weeks of age. These mice were divided into 5 groups,i.e. the diabetic control group,Shuyu Pill + Longxuejie Capsules group,Shuyu Pill group,Longxuejie Capsules group,and Metformin group-by fasting blood sugar and weight, 16 in each group. Another 16 C57/BL6 mice were recruited as the normal healing group. After building wound models of full-thickness skin loss,all mice were administrated for 14 days...