期刊论文

Effect of Compound Uncaria Antihypertensive Tablet on Protein Expression of CT-1 /JAK-STAT Pathway in Rats

中文

中国中西医结合杂志

1003-5370

2019

39

2

206-210

10.7661/j.cjim.20180731.218

国家自然科学基金项目(No.81473616) 湖南省中医药科研计划重点项目(No.201534) 湖南省教育厅重点项目资助(No.15A142) 中医内科学省部共建教育部重点实验室开放基金资助项目(No.ZYNK201507).

本校为第一机构

目的观察复方钩藤降压片对自发性高血压大鼠(SHR)心肌营养素-1(CT-1) /JAK-STAT通路蛋白表达影响,探讨其干预逆转高血压左室肥厚的机制。方法将50只SHR按随机数字表法分为5组,复方钩藤降压片高剂量组(H组,129. 6 mg /mL) 、复方钩藤降压片中剂量组(M组,86. 4 mg /mL) 、复方钩藤降压片低剂量组(L组,43. 2 mg /mL) 、贝那普利组(B组,0. 9 mg /mL) 、SHR模型对照组(S组) ,每组10只,另选取10只Wistar大鼠为正常对照组(W组) ,每天灌胃1次,持续干预24周后取材,采用免疫组化法检测心肌局部CT-1的含量,Western blot法检测心肌JAK1 /STAT3蛋白表达水平。结果与W组比较,S组心肌组织中CT-1表达量和JAK1、S...

Objective To explore the mechanism of reversing left ventricular hypertrophy in spontaneous hypertension rats (SHR) by the intervention of Compound Uncaria Antihypertensive Tablet from the point of view of interfering with the protein expression of cardiotrophin-1 (CT-1) /JAK-STAT pathway in rats' cardiac myocardium. Methods Totally 50 SHR were divided into 5 groups,the high dose group (group H,129. 6 mg /mL) ,the middle dose group (group M,86. 4 mg /mL) ,the low dose group (group L,43. 2 mg /mL) ,the benazepril group (group B,0. 9 mg /mL) ,and the SHR model control group (group S) according t...