期刊论文

中文

中国中西医结合杂志

1003-5370

2020

40

12

1484-1488

10.7661/j.cjim.20200410.227

湖南省中医药科研计划项目(No.201516) 湖南省教育厅科学研究项目(No.16A158) 湖南中医药大学中医学国内一流建设学科(湘教通[2018]469号)。

本校为第一机构

目的 探讨心痛泰颗粒预防性给药对动脉粥样硬化(AS)兔Toll样受体4(TLR4)、p38丝裂原活化蛋白激酶(p38 MAPK)蛋白及mRNA表达的影响.方法 120只兔随机分为空白组(K),模型组(M),心痛泰颗粒高(G)、中(Z)、低(D)剂量组和瑞舒伐他汀组(R),每组20只.K组喂养基础饲料,其余各组均采用高脂饲料喂养联合免疫损伤复制AS模型.在造模同时,G、Z、D、R组每天给药剂量分别为1.44、0.72、0.36 g/kg及0.55 mg/kg,K组与M组灌服同等体积的生理盐水,共8周.观察主动脉组织的病理形态学变化,并检测血脂含量及主动脉TLR4、p38MAPK蛋白及mRNA的表达量.结果 M组内膜壁明显增厚,有大量的泡沫细胞聚集及炎性细胞浸润,中膜细胞...

Objective To explore the effect of preventive administration of Xintongtai Granule(XG)on mR-NA and protein expression level of toll like receptor 4(TLR4)and p38 mitogen-activated protein kinase(p38 MAPK)in aorta tissue of atherosclerosis(AS)rabbits.Methods Totally 120 rabbits were randomly divided into the blank control group(K),the model group(M),the low dose XG group(D,0.36 g/kg),the middle dose XG group(Z,0.72 g/kg),the high dose XG group(G,1.44 g/kg),and the rosuvastatin group(R,0.55 mg/kg),20 in each group.Except those in the K group were fed with basic diet,all other rabbits were fed wit...