期刊论文

Effect of Zicui Tongmai Decoction on PI3K Signaling Pathway in Skeletal Muscle of Rats with Diabetes

中文

中国中西医结合杂志

1003-5370

2021

41

06

711-716

10.7661/j.cjim.20210224.066

湖南省中医药管理局一般项目（No.201659）；

本校为第一机构

目的探讨滋膵通脉饮对糖尿病大鼠血糖、胰岛素抵抗和骨骼肌磷脂酰肌醇-3激酶(PI3K)信号通路的影响。方法45只清洁级SD大鼠,随机数字表法抽取10只作为空白对照组,剩余35只采用高脂高糖饲料喂养及腹腔注射链脲佐菌素的方法构建2型糖尿病大鼠模型,将造模成功的糖尿病大鼠随机分为3组:模型组、滋膵通脉饮组和罗格列酮组,每组10只。于实验第7周开始灌胃,滋膵通脉饮组灌服滋膵通脉饮,生药量为17.6 g/kg;罗格列酮组灌服罗格列酮混悬液0.42 mg/(kg·d);空白对照组和模型组均灌服同等容积的蒸馏水,每日1次,共用药4周。4周后称取大鼠体重,测大鼠血糖、胰岛素,计算胰岛素抵抗指数,半定量PCR技术检测大鼠骨骼...

Objective To explore the effects of Zicui Tongmai Decoction(ZCTMD)on blood glucose,insulin resistance and phosphatidylinositol 3-kinase(PI3K)signaling pathway in skeletal muscle of diabetic rats.Methods Ten of the 45 SD rats(clean grade)were selected as control group using random number table,the remaining 35 rats were fed with high-fat and high sugar diet,combined with intraperitoneal injection of streptozotocin to establish the model of type 2 diabetes.The successfully established diabetic rats were randomly divided into three groups:model gr...