Data Mining and Systems Pharmacology to Elucidate Effectiveness and Mechanisms of Chinese Medicine in Treating Primary Liver Cancer

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成果类型：

期刊论文

作者：

Zhang, Zhen;Li, Jun-wei;Zeng, Pu-hua;Gao, Wen-hui;Tian, Xue-fei

通讯作者：

Xue-fei Tian

作者机构：

[Tian, Xue-fei; Zhang, Zhen] Hunan Univ Chinese Med, Coll Integrated Chinese & Western Med, Dept Internal Med, Changsha 410208, Peoples R China.

[Tian, Xue-fei; Zhang, Zhen; Gao, Wen-hui] Hunan Univ Chinese Med, Hunan Key Lab TCM Prescript & Syndromes Translat, Changsha 410208, Peoples R China.

[Li, Jun-wei] Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Pharm, Shenzhen 518020, Guangdong, Peoples R China.

[Li, Jun-wei] Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China.

[Zeng, Pu-hua] Hunan Acad Tradit Chinese Med, Affiliated Hosp, Dept Oncol, Changsha 410006, Peoples R China.

通讯机构：

[Xue-fei Tian] D

Department of Internal Medicine, College of Integrated Chinese and Western Medicine of Hunan University of Chinese Medicine, Changsha, China<&wdkj&>Hunan Key Laboratory of TCM Prescription and Syndromes Translational Medicine, Hunan University of Chinese Medicine, Changsha, China

语种：

英文

关键词：

Chinese medicine;primary liver cancer;system pharmacology;bioinformatics;tumor microenvironment

期刊：

中国结合医学杂志

ISSN：

1672-0415

年：

2022

卷：

期：

页码：

636-643

DOI：

10.1007/s11655-021-3449-8

基金类别：

Supported by the National Natural Science Foundation of China (No. 82074450), Natural Science Foundation of Hunan Province (No. 2020JJ4066), Postgraduate Innovation Project of Hunan University of Chinese Medicine in 2020 (No. 2020CX14), “YIFANG” Postgraduate Innovation Project of Hunan University of Chinese Medicine (No. 2020YF04)

机构署名：

本校为其他机构

院系归属：

中西医结合学院

摘要：

Objective: To identify specific Chinese medicines (CM) that may benefit patients with primary liver cancer (PLC), and to explore the mechanism of action of these medicines. Methods: In this retrospective, singlecenter study, prescription information from PLC patients was used in combination with Traditional Chinese Medicine Inheritance Supports System to identify the specific core drugs. A system pharmacology approach was employed to explore the mechanism of action of these medicines. Results: Taking CM more than 6 months was significantly asso...

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