期刊论文

Qingwen Baidu Decoction Regulated Mouse Alveolar Macrophages Autophagy to Reduce Sepsis Induced Lung Injury via Inhibiting TLR4/NF-κB Signaling Pathway: an Experimental Study

中文

中国中西医结合杂志

1003-5370

2023

43

3

315-322

10.7661/j.cjim.20220815.320

湖南省中医药科研计划项目青年基金（No.2021175）； 湖南省卫健委一般项目（No.202117011236）； 湖南中医药大学校级科研联合基金一般项目（No.2020XJJJ041）；

本校为第一机构

目的 探讨清瘟败毒饮调控小鼠肺泡巨噬细胞自噬减轻脓毒症肺损伤的机制。方法 将60只C57BL/6小鼠按随机数字表法分为空白组、模型组、清瘟败毒饮低、中、高剂量组及地塞米松组，每组10只。采用腹腔注射脂多糖（LPS）建立脓毒症肺损伤动物模型。清瘟败毒饮各剂量组每天分别予607.75、1 215.5、2 431 mg/kg灌胃，每日1次；地塞米松组予尾静脉注射地塞米松1.3 mg/kg，每日1次；空白组予以等量生理盐水腹腔注射，模型组予以腹腔注射生理盐水，干预时间均为1周。实验结束时，用HE染色观察小鼠肺组织的病理学改变，计算肺组织病理学评分，取肺组织称重测定湿重/干重比，蛋白免疫印迹法（Western Blot）...

Objective To study the mechanism of Qingwen Baidu Decoction(QWBDD) in regulating autophagy of mouse alveolar macrophages and alleviating sepsis induced lung injury. Methods A total of 60C57BL/6 mice were divided into blank group,model group,low, medium, high dose QWBDD ...MORE Objective To study the mechanism of Qingwen Baidu Decoction(QWBDD) in regulating autophagy of mouse alveolar macrophages and alleviating sepsis induced lung injury. Methods A total of 60C57BL/6 mice were divided into blank group,model group,low, medium, high dose QWBDD gr...