Buyang Huanwu Decoction Promotes Recovery after Spinal Cord Injury by Regulating cAMP/PKA/NF-κB p65 Pathway

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成果类型：

期刊论文

作者：

Li, Si-yuan;Fan, Ting-ting;Yin, Jian;Wan, Cai-yun;Li, Mei-li;...

通讯作者：

Li, L

作者机构：

[Li, Liang; Xia, Shuai-shuai; Li, Mei-li; Fan, Ting-ting; Wan, Cai-yun; Li, Si-yuan] Hunan Univ Chinese Med, Prov Key Lab Tradit Chinese Med Diagnost, Changsha 410208, Peoples R China.

[Li, Liang; Xia, Shuai-shuai; Li, Mei-li; Fan, Ting-ting; Wan, Cai-yun; Li, Si-yuan] Hunan Univ Chinese Med, Key Lab TCM Heart & Lung Syndrome Differentiat & M, Changsha 410208, Peoples R China.

[Yin, Jian; Li, Mei-li] Hunan Univ Chinese Med, Dept Anat, Changsha 410208, Peoples R China.

[Li, Qiang] Hunan Brain Hosp, Dept Tradit Chinese Med, Changsha 410007, Peoples R China.

通讯机构：

[Li, L ] H

Hunan Univ Chinese Med, Prov Key Lab Tradit Chinese Med Diagnost, Changsha 410208, Peoples R China.

Hunan Univ Chinese Med, Key Lab TCM Heart & Lung Syndrome Differentiat & M, Changsha 410208, Peoples R China.

语种：

英文

关键词：

Buyang Huanwu Decoction;spinal cord injury;cyclic adenosine monophosphate;protein kinase a;nuclear factor kappa-B;brain-derived neurotrophic factor;Chinese medicine

期刊：

中国结合医学杂志

ISSN：

1672-0415

年：

2025

页码：

1-9

DOI：

10.1007/s11655-025-4201-6

基金类别：

National Natural Science Foundation of China [82374323]; Natural Science Foundation of Hunan Province [2022JJ30435]; Research Project of Hunan Provincial Health Commission [C202302087602]; Chinese Medicine Science & Research Project of Hunan Province [A2023044]; Science and Technology Innovation Project of Hunan Province [2020SK50804]; Graduate Student Innovation Project of Hunan University of Chinese Medicine [2023CX180]

机构署名：

本校为第一且通讯机构

院系归属：

中医学院

中医诊断研究所

摘要：

OBJECTIVE: To investigate whether Buyang Huanwu Decoction (BYHWD) had a good curative effect on the neuroprotection of red nucleus neurons after spinal cord injury (SCI) and the possible molecular mechanism. METHODS: Ninety male Sprague-Dawley rats were divided into 5 groups (n=18 per group) according to a random number table, including the control, model, low- (12.78 g/kg, BL group), medium- (25.65 g/kg, BM group), and high-dose BYHWD groups (51.30 g/kg, BH group). A rubrospinal tract transection model in rats was established, and different do...

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Buyang Huanwu Decoction Promotes Recovery after Spinal Cord Injury by Regulating cAMP/PKA/NF-κB p65 Pathway

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