期刊论文

Chen, XY

英文

Cellular and Molecular Biology

0145-5680

2023

69

4

94-100

10.14715/cmb/2023.69.4.14

Department of Chinese Medicine Education in China [2022-75]; National Natural Science Foundation of China [81704061, 81173213]; Hunan province innovative province construction special fight against new Coronavirus pneumonia project [2020SK3009]; Ramp;D plan for key areas of the Hunan Provincial Department of Science and Technology [2019SK2321]; Hunan science and technology talent hosting project [2020TJ-N01]; Hunan Development and Reform Commission Innovation Guidance Project (Hunan Development and Reform Investment) [2019-412]; Special Project for the Construction of Key Laboratory of 'Four Seasons Adjusting Yang' for Heart Disease (Xiang TCM Letter51); Hunan Engineering Research Center for Preventive Treatment of Diseases in 'Four Seasons Adjusting Yang' [1006]; Hunan University of Traditional Chinese Medicine first-class discipline open fund [2022ZYX01, 2022ZYX11, 2021ZYX41]

本校为第一且通讯机构

The homing rate of transplanted mesenchymal stem cells (BMSCs) after acute myocardial infarction (AMI) is generally low, with only 0%-6% of the number of transplanted stem cells distributed to the heart; therefore, this study will investigate the therapeutic effects and mechanisms of miR-183-5p-modified BMSCs cells on myocardial ischemia and hypoxia caused by AMI. In this experiment, After first establishing the BMSCs ischemic-hypoxic injury model, the rats were divided into healthy group, model group, BMSCs group and BMSCs+ miR-183-5P group, where the healthy group was taken to normal culture...