期刊论文

Effects of the original and modified Qi-Boosting Toxin-Resolving Formulae on moving potentiality and cellular pseudopod of NPC cell line CNE2Z

中文

中国中西医结合耳鼻咽喉科杂志

1007-4856

2011

19

6

386-391

10.3969/j.issn.1007-4856.2011.06.003

81072904,30973856:国家自然科学基金 2009FJ3202:湖南省科技厅项目 06WK3016:湖南省科技厅国际科技合作项目

本校为其他机构

目的 研究益气解毒法不同组方对鼻咽癌细胞迁徙运动潜能及其细胞伪足的影响.方法 以正常大鼠血浆为对照,分别应用益气解毒方原方及其改方大鼠药物血浆对CNE2Z细胞进行干预,采用划痕实验法评价不同组方药物对靶细胞迁徙运动潜能的影响,以扫描电镜观察细胞伪足形态特征,分析靶细胞的反应特性.结果 益气解毒原方对CNE2Z细胞的迁徙运动潜能显示抑制效应,细胞迁徙能力较差,伪足伸展不明显;益气解毒改方则对靶细胞迁徙运动潜能显示为促进效应,细胞伪足伸展长度较长.结论 同为益气解毒法的组方,由于剂量构成比不同,各方对鼻咽癌细胞迁徙运动潜能的药效学差异巨大.这样的药理效应特点,对中药复方的合理组...

Objective To investigate the effects of original and modified Qi-Boosting Toxin-Resolving Formulae （QBTRF） on moving potentiality and cellular pseudopod of nasopharyngeal carcinoma cell line CNE2Z based on an experimental study. Methods Investigated were the effects of two herbal medicinal formulae, the original and modified QBTRF, on moving potentiality and cellular pseudopod of NPC cell line CNE2Z by medicinal blood plasma assaying procedures, with healthy rat plasma as the control in a routine way. Here, scratch test was taken to determine...