目的探讨戊己丸对幽门螺旋杆菌(Helicobacter pylori, H. pylori)感染胃炎小鼠的疗效与胃肠道微生物及酶活性的关系, 从微生态学角度研究戊己丸的疗效机制。方法通过建立H. pylori感染胃炎小鼠模型, 随机分为正常组、模型组、克拉霉素组、戊己丸组, 分别灌胃给药克拉霉素、戊己丸, 分析胃内菌群数及酶活性。结果模型组中的细菌数、大肠埃希菌数、双歧杆菌数及乳酸菌数较正常组有显著性或极显著性增加(P
摘要(英文):
Objective To explore the relationship between the efficacy of Wuji Wan on Helicobacter pylori( H. pylori) infected mice with gastritis and gastrointestinal microbiotia and enzyme activity. Methods Mouse models of gastritis correlated with H. pylori infection was established and given Wuji Wan and clarithromycin respectively,then the gastrointestinal microbiota and enzyme activities were analysed. Results The counts of bacteria,Escherichia coli,Bifidobacteria and Lactic acid bacteria in the model group were significantly higher than those in t...