Dendrobium polysaccharide (DOP) ameliorates the LL‐37‐induced rosacea by inhibiting NF‐κB activation in a mouse model

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zeng, Bijun;Yang, Zhibo;Jiang, Gufen;Zhou, Hongxia;Zhang, Yujin;...

通讯作者：

Yang, ZB

作者机构：

[Chen, Zi; Zeng, Bijun; Wang, Chang; Peng, Youhua; Zhang, Yujin; Yang, Zhibo; Jiang, Gufen; Yan, Yining; Zhou, Hongxia] Hunan Univ Chinese Med, Affiliated Hosp 2, Dept Dermatol, Domest First Class Discipline Construct Project C, Changsha, Hunan, Peoples R China.

[Zeng, Bijun] Hunan Univ Chinese Med, Hunan Engn Technol Res Ctr Med & Funct Food, Changsha, Peoples R China.

[Yang, Zhibo] Hunan Univ Chinese Med, Affiliated Hosp 2, Dept Dermatol, Domest First Class Discipline Construct Project C, Changsha 410005, Hunan, Peoples R China.

通讯机构：

[Yang, ZB ] H

Hunan Univ Chinese Med, Affiliated Hosp 2, Dept Dermatol, Domest First Class Discipline Construct Project C, Changsha 410005, Hunan, Peoples R China.

语种：

英文

关键词：

dendrobium polysaccharide (DOP);inflammation;rosacea;the TLR4/NF-κB pathway

期刊：

Skin Research and Technology

ISSN：

0909-752X

年：

2024

卷：

期：

页码：

e13543-

DOI：

10.1111/srt.13543

基金类别：

Scientific Research Project of Hunan Provincial Department of Education; Key project of the Hunan Provincial Administration of Traditional Chinese Medicine [A2023056]; First-level Discipline Open Fund Project of Nursing in Hunan University of Traditional Chinese Medicine [2020HLX02]; Hunan Province High-tech Industry Science and Technology Innovation Leading Program (Science and Technology Research) [2020SK2023]; Natural Science Foundation of Hunan Province [2020JJ5431]; [20A372]

机构署名：

本校为第一机构

院系归属：

第二中医临床医学院

摘要：

BACKGROUND: Rosacea, a common chronic inflammatory skin disease worldwide, is currently incurable with complex pathogenesis. Dendrobium polysaccharide (DOP) may exert therapeutic effects on rosacea via acting on the NF-κB-related inflammatory and oxidative processes. MATERIALS AND METHODS: In this study, an LL-37-induced rosacea-like mouse model was established. HE staining was used to assess the skin lesions, erythema severity scores, pathological symptoms, and inflammatory cell numbers of mice in each group. The inflammation level was quanti...

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Dendrobium polysaccharide (DOP) ameliorates the LL‐37‐induced rosacea by inhibiting NF‐κB activation in a mouse model

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