Dynorphin activation of kappa opioid receptor reduces neuronal excitability in the paraventricular nucleus of mouse thalamus

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Chen, Zhiheng;Tang, Yamei;Tao, Huai（陶怀）;Li, Cunyan;Zhang, Xianghui;...

通讯作者：

Liu, Yong

作者机构：

[Chen, Zhiheng] Cent S Univ, Xiangya Hosp 2, Dept Pediat, Changsha 410013, Hunan, Peoples R China.

[Li, Cunyan; Tang, Yamei] Cent S Univ, Xiangya Hosp 2, Dept Lab, Changsha 410011, Hunan, Peoples R China.

[Tao, Huai] Hunan Univ Chinese Med, Dept Biochem & Mol Biol, Changsha 410208, Hunan, Peoples R China.

[Zhang, Xianghui; Liu, Yong] Cent S Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R China.

[Liu, Yong] Cent S Univ, Xiangya Hosp 2, Mental Hlth Inst, 139 Renmin Middle Rd, Changsha 410011, Hunan, Peoples R China.

通讯机构：

[Liu, Yong] C

Cent S Univ, Xiangya Hosp 2, Mental Hlth Inst, 139 Renmin Middle Rd, Changsha 410011, Hunan, Peoples R China.

语种：

英文

关键词：

Drug reward;Dynorphin;Kappa opioid receptor;Paraventricular nucleus of thalamus

期刊：

Neuropharmacology

ISSN：

0028-3908

年：

2015

卷：

期：

页码：

259-269

DOI：

10.1016/j.neuropharm.2015.05.030

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81171268]

机构署名：

本校为其他机构

院系归属：

医学院

中医学院

摘要：

It has been reported that kappa opioid receptor (KOR) is expressed in the paraventricular nucleus of thalamus (PVT), a brain region associated with arousal, drug reward and stress. Although intra-PVT infusion of KOR agonist was found to inhibit drug-seeking behavior, it is still unclear whether endogenous KOR agonists directly regulate PVT neuron activity. Here, we investigated the effect of the endogenous KOR agonist dynorphin-A (Dyn-A) on the excitability of mouse PVT neurons at different developmental ages. We found Dyn-A strongly inhibited PVT neurons through a direct postsynaptic hyperpol...

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Dynorphin activation of kappa opioid receptor reduces neuronal excitability in the paraventricular nucleus of mouse thalamus

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