期刊论文

中文

云南中医学院学报

1000-2723

2016

39

6

14-16

10.19288/j.cnki.issn.1000-2723.2016.06.004

陕西省教育厅自然专项计划基金项目（15JK1212）；

本校为其他机构

目的 探讨壮骨止痛方对骨质疏松大鼠核因子κB受体活化因子(receptor activator of NF-κB,RANK)、核因子κB受体活化因子配体(receptoractivator of NF-κB ligand,RANKL)和骨保护素(osteoprotegrin,OPG)表达的影响.方法 将实验动物分为假手术组、模型组、壮骨止痛方高剂量治疗组、壮骨止痛方低剂量治疗组、雌二醇组5组,用酶联免疫免法测定大鼠血清中OPG、RANKL的水平.结果 模型组大鼠血清OPG降低、RANKL水平升高,经壮骨止痛方药物干预后,大鼠血清OPG水平明显下降、RANKL水平明显下降.结论 壮骨止痛方药物可以降低大鼠血清RANKL/OPG的比值,激活RANKL/RANK/OPG信号系统,达到预防治疗骨质疏松的作...

Objective To study about Strong Bone Pain Side All action on osteoporosis female on the expression of receptor activator of NF-κB （RANK）, receptoractivator of NF-κB ligand （RANKL） and osteoprotegrin （OPG）. Methods Rat was randomly divided into five groups：control group, OP model group and Strong Bone Pain Side All high dose treatment group, Strong Bone Pain Side All lower dose treatment groups, estradiol group. Determination of OPG and RANGKL in rat serum by ELISA. Results Serum OPG of model group rats decreased and RANGKL levels incre...