期刊论文

中文

中国病原生物学杂志

1673-5234

2011

06

1

32-34

10.13350/j.cjpb.2011.01.007

湖南省科技厅资助项目（No.04sk1007-26）；

本校为第一机构

目的 观察加味四逆散对血吸虫病肝纤维化小鼠肝功能的影响. 方法 NIH小鼠经皮肤人工感染血吸虫尾蚴后随机分为4组:B组(模型组)、C组(吡喹酮组)、D组(吡喹酮+加味四逆散组)和E组(吡喹酮+秋水仙碱组),同时设A组(正常对照组).病理观察小鼠肝组织肝纤维化形成后第21 d开始给药治疗,C组、D组、E组在第45 d时予以吡喹酮一次性灌胃杀虫.第78 d心脏采血.生物化学法测血清ALT、TBiL及血浆ALB含量,取肝、脾组织称莺,计算脏器系数. 结果 吡唪酮+加味四逆散组小鼠治疗后肝脏系数低于模型组、吡喹酮组、吡喹酮+秋水仙碱组(P

Objective To evaluate the effect of modified SiNi powder,known as Jiawei Sinisan（JWSNS）,on liver function in a murine model of liver fibrosis induced by Schistosoma japonicum infection.Methods Liver fibrosis was successfully induced in NIH mice by infection with cercaria of S.japonicum and then mice were randomly divided into groups B,C,D and E.The mice in groups C,D,and E were treated with praziquantel,praziquantel plus JWSNS,and praziquantel plus colchicine,respectively.In addition,a group of uninfected NIH mice（group A） served as the con...