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Liquiritigenin Blocks Breast Cancer Progression by Inhibiting Connective Tissue Growth Factor Expression via Up-Regulating miR-383-5p

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成果类型:
期刊论文
作者:
Zhang, Zhanwei;Lin, Jie;Hu, Jinhui;Liu, Lifang*
通讯作者:
Liu, Lifang
作者机构:
[Zhang, Zhanwei; Lin, Jie] Hunan Univ Chinese Med, Grad Sch, Changsha, Peoples R China.
[Zhang, Zhanwei] Hunan Univ Chinese Med, Affiliated Hosp 1, Dept Chinese Tradit Surg, Changsha, Peoples R China.
[Liu, Lifang; Hu, Jinhui] Hunan Univ Chinese Med, Affiliated Hosp 1, Dept Breast Surg, 95 Mid Shaoshan Rd, Changsha 410007, Hunan, Peoples R China.
通讯机构:
[Liu, Lifang] H
Hunan Univ Chinese Med, Affiliated Hosp 1, Dept Breast Surg, 95 Mid Shaoshan Rd, Changsha 410007, Hunan, Peoples R China.
语种:
英文
关键词:
Liquiritigenin;MiR-383-5p;connective tissue growth factor;breast cancer;traditional Chinese medicine
期刊:
International Journal of Toxicology
ISSN:
1091-5818
年:
2022
卷:
41
期:
1
页码:
5-15
基金类别:
Key Project of Hunan Province Traditional Chinese Medicine Scientific Research Project [2021009]; Hunan Province Clinical Medical Technology Innovation Guidance Project [2020SK51402]
机构署名:
本校为第一且通讯机构
院系归属:
第一中医临床学院
研究生院
摘要:
The objective of this study was to investigate the effect of liquiritigenin (LQ) on breast cancer (BC) and its mechanism. After BC cell lines and normal mammary epithelial cells were cultured with LQ, CCK-8, and Scratch, Transwell assays and flow cytometry were applied to test the effect of LQ on cell proliferation, migration, invasion, and apoptosis. The effect of LQ on the expression of microRNA-383-5p (miR-383-5p) and connective tissue growth factor (CTGF) was measured by qRT-PCR and Western blotting. Bioinformatics prediction was used to ev...

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