Up-regulation of the HSP72 by Foxa1 in MCF-7 human breast cancer cell line

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成果类型：

期刊论文

作者：

Song, Lan*;Xu, Zhaojun;Zhang, Caiping;Qiao, Xinhui;Huang, Chunling

通讯作者：

Song, Lan

作者机构：

[Huang, Chunling; Qiao, Xinhui; Zhang, Caiping; Song, Lan] Nanhua Univ, Coll Life Sci, Dept Biochem & Mol Biol, Hengyang 421001, Hunan, Peoples R China.

[Song, Lan] Cent S Univ, Lab Shock, Dept Pathophysiol, Xiangya Sch Med, Changsha 410078, Hunan, Peoples R China.

[Xu, Zhaojun] Hunan Univ Tradit Chinese Med, Cardiothorac Surg Affiliated Hosp 1, Changsha 41007, Hunan, Peoples R China.

通讯机构：

[Song, Lan] N

Nanhua Univ, Coll Life Sci, Dept Biochem & Mol Biol, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Forkhead box A1;Gene expression;HSP72

期刊：

Biochemical and Biophysical Research Communications

ISSN：

0006-291X

年：

2009

卷：

386

期：

页码：

30-34

DOI：

10.1016/j.bbrc.2009.05.120

基金类别：

This work was support by fundings from the Nature Science Foundation of Hunan Province, China (08JJ3030) and the Science Foundation of Health Department of Hunan, China (2007B090).

机构署名：

本校为其他机构

院系归属：

第一中医临床学院

摘要：

Forkhead box protein A1 (Foxa1) is an evolutionarily conserved winged helix transcription factor. In this study, the effect of Foxa1 on the expression of HSP72 was examined by RT-PCR and Western blot in Foxa1 overexpression or deficient cells. The results showed overexpression of Foxa1 promoted the expression of HSP72, while Foxa1 depletion, induced by antisense oligonucleotides, decreased the expression of HSP72 in MCF-7 cells under normal and heat stress condition. Electrophoretic mobility shift assay and chromatin immunoprecipitation reveale...

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Up-regulation of the HSP72 by Foxa1 in MCF-7 human breast cancer cell line

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