Intermittent fasting attenuates lipopolysaccharide-induced acute lung injury in mice by modulating macrophage polarization

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成果类型：

期刊论文

作者：

Ma, Li;Chen, Yan-Qing;You, Zhi-Jian;Jiang, Zhong-Sheng;Fang, Yu;...

作者机构：

[Dong, Liang; You, Zhi-Jian; Chen, Yan-Qing; Ma, Li] Liuzhou Peoples Hosp, Dept Anesthesiol, Liuzhou 545006, Guangxi, Peoples R China.

[Jiang, Zhong-Sheng] Liuzhou Peoples Hosp, Dept Infect, Liuzhou 545001, Guangxi, Peoples R China.

[Fang, Yu] Hunan Univ Chinese Med, Hosp 1, Pathol Ctr, Changsha 410021, Hunan, Peoples R China.

[Fang, Yu] Hunan Univ Chinese Med, Hosp 1, Med Lab, Changsha 410021, Hunan, Peoples R China.

语种：

英文

关键词：

Acute lung injury;intermittent fasting;macrophage polarization;PPARγ;AMPK;ALI;acute lung injury;AMPK;AMP-activated protein kinase;ANOVA;one-way analysis of variance;BCA;bicinchoninic acid;BMDMs;bone marrow-derived macrophages;DMEM;Dulbecco's Modified Eagle Medium;ELISA;enzyme-linked immunosorbent assay;LPS;lipopolysaccharide;IL-6;interleukin-6;IL-1β;interleukin-1β;IF;intermittent fasting;MDA;malondialdehyde;MPO;myeloperoxidase;PPARγ;peroxisome proliferator-activated receptor gamma;TNF-α;tumor necrosis factor-α

期刊：

Journal of Nutritional Biochemistry

ISSN：

0955-2863

年：

2022

卷：

110

页码：

109133

DOI：

10.1016/j.jnutbio.2022.109133

基金类别：

High-level introduction of talent research start-up fund [LRYGCC202111, LRYGCC202108]; Selffunded scientific research project of Health Commission of Guangxi [Z20210219]; Guangxi Natural Science Foundation [AD2203056, 2021AC19352]

机构署名：

本校为其他机构

院系归属：

第一中医临床学院

摘要：

Acute lung injury (ALI) is a spectrum of acute and life-threatening pulmonary inflammatory conditions. Treatment of ALI remains a clinical challenge. Recently, intermittent fasting (IF) has been shown to improve health and alleviate many diseases. In this study, we tested whether IF attenuated ALI and investigated the mechanism underlying this process. In vivo , the effects of IF on ALI were evaluated in a lipopolysaccharide (LPS)-induced murine ALI model. We found that two times of 24-h fasting in a week before ALI efficiently ameliorated LPS-induced lung injury in mice, characterized by alle...

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Intermittent fasting attenuates lipopolysaccharide-induced acute lung injury in mice by modulating macrophage polarization

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