Hydrostatic pressure has direct effect on vascular endothelium. Endothelial lipase (EL) is a newly identified member, only secreted by endothelial cells, of the triglycerides lipase family. EL may be one important determinants of HDL-metabolism and inflammation acting at the vessel wall. However, little is known about regulation of EL at the vessel wall. The effect of hydrostatic pressure on EL and its possible mechanism were investigated. In human umbilical vein endothelial cells, increasing pressures (120, 150 and 180 mmHg) treatment in a custom-made pressure incubator increased the mRNA and...
