期刊论文

The Roles of CC Chemokine in Myocardial Infarction

Chen Nai-Hong

中文

生物化学与生物物理进展

1000-3282

2020

47

10

1046-1055

10.16476/j.pibb.2020.0083

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81900488]; Henan University of Chinese Medicine First-class Disciple Construction Project [201803]; Henan Engineering Technology of Standardization and Function of Chinese Herbal Decoction Pieces [2016TP2008]; Open Fund of Henan Engineering Technology of Standardization and Function of Chinese Herbal Decoction Pieces [BG201701, 0101003004]; Natural Science Foundation of Henan Province [2015JJ50549]

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CC类趋化因子亚家族是趋化因子家族中成员最多、研究最广泛的一大类细胞因子,其主要功能是参与炎症细胞激活、迁移、黏附等病理生理过程.大量研究表明,CC类趋化因子亚家族成员参与了心肌梗死后病理过程的各个阶段.其中研究最为深入的是单核细胞趋化蛋白1(monocyte chemoattractant protein-1,MCP-1)及其受体CC趋化因子受体2(CC chemokine receptor 2,CCR2).MCP-1和CCR2在心肌梗死后炎症期、增殖期及疤痕愈合期都发挥了重要作用从而影响梗死后心室重构.近年来,CC类趋化因子亚家族其他成员亦被逐渐揭示参与了心肌梗死的发展.本文结合以往大量文献,就CC类趋化因子亚家族在心肌梗死各个阶段中的作用...

Th CC chemokines is the largest and most widely studies group of chemokines, which play a critical role in inflammatory leukocyte locomotion, trafficking and adhesion. The chemokine CC subfamily are involed in the pathogenesis of myocardial infarction. Monocyte chemoattractant protein-1 (MCP-1) and its receptor CC Chemokine receptor 2 (CCR2), as most studied chemokine, plays an important role in post-infarction inflammation, proliferation and scar formation, thus affecting ventricular remodeling after myocardial infarction. In recent years other members of the CC chemokines have been gradually...