期刊论文

花榈木提取物对慢性不可预知应激小鼠认知损害的影响

Guo Jian-Sheng;Zeng Gui-Rong

中文

生物化学与生物物理进展

1000-3282

2020

47

8

768-779

10.16476/j.pibb.2020.0291

supported by grants from Hunan province science and technology plan projects of China （2015DK3010）； Major Scientific and Technological Project of Guizhou Province （Qiankehe J Major Character20152002-2-5）； Guizhou Science and Technology Fund（Qiankehe JZ 20142003,20161016,20191038）~~；

本校为第一且通讯机构

认知缺陷是抑郁症的核心症状之一,已成为抑郁症治疗面临的的一大挑战.花榈木为我国南方广泛分布的一种绿色乔木,具有抗抑郁作用.然而,花榈木对认知损害的作用尚未见报道.本研究旨在探讨花榈木提取物对慢性应激引起的认知障碍的影响,通过建立小鼠慢性不可预测轻度应激(CUMS)模型,评价花榈木改善认知功能的作用.认知行为采用新物识别和Morris水迷宫测试,免疫组织化学分析海马组织中GFAP和Aβ蛋白的水平,Western Blotting分析海马组织NLRP3、TNF-α和IL-1β蛋白表达.结果显示,花榈木提取物能明显增加小鼠的物体识别辨别指数,明显减少定位航行小鼠平台潜伏期,增加平台穿越次数.花榈木提取物能显著提...

Cognitive deficits were one of the core symptoms of depression, which has become a major challenge in the treatment of depression. Ormosia hemyi Prain (OHP) is a green perennial tree widely distributed in southern China. Although OHP was demonstrated to function in antidepression, its effect on cognitive deficits still remains to be elucidated. The aim of the present study was to investigate the effect of OHP on cognitive deficits caused by chronic stress. A mice model of chronic unpredictable mild stress (CUMS) was employed to evaluate the cognitive improvement effect of OHP. Cognitive behavi...