期刊论文

CKLF1 as a Potential Therapeutic Target for Ischemic Stroke

Chen Nai-Hong;Chu Shi-Feng

英文

生物化学与生物物理进展

1000-3282

2022

49

1

126-138

10.16476/j.pibb.2021.0256

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81873026, 82074044, 81730096]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7192135]; Key R&D Program of Shanxi Province [201803D421006]; CAMS Innovation Fund for Medical Sciences (CIFMS) [2016-I2M-1-004]

本校为第一且通讯机构

Ischemic stroke is a kind of stroke in which the blood supply to the brain is disrupted, resulting in serious neurological deficits. Among stroke patients, about 87% of the cases are ischemic stroke. Neuroinflammation is one of the main pathological conditions of stroke injury. CKLF1 is a non-classical CC-type chemokine discovered in 2001, which showed strong chemotactic activity on monocytes, neutrophils, and lymphocytes. CKLF1 is most abundant in the fetal brain, but absent in the healthy adult. Growing evidence shows that CKLF1 is reactivated and expressed in adult stroke animal models and ...

缺血性脑卒中是一种血液循环障碍疾病,可导致严重的神经功能缺损。卒中病人中约有87%的病例为缺血性卒中。神经炎症是中风损伤的主要病理状态之一。CKLF1是2001年发现的非经典CC型趋化因子,对单核细胞、中性粒细胞和淋巴细胞表现出很强的趋化活性。CKLF1在胎儿大脑中含量最高,但在健康成人阶段不存在。越来越多的证据表明,CKLF1表达在成年卒中动物模型中,并被重新激活,参与神经炎症反应的多个过程。然而,其生物活性和药物发现的发展仍缺乏系统的文献报道。因此,我们收集已发表的资料并做此综述,简要阐明CKLF1在缺血性脑卒中中的作用,并解释其加重缺血性脑卒中的机制。此外,还发现了一些潜在的抗...