期刊论文

Liang, H

中文

生物化学与生物物理进展

1000-3282

2023

50

03

486-496

10.16476/j.pibb.2022.0180

National Natural Science Foundation of China [81774208]; China Postdoctoral Science Foundation Project [2020M682578]; Research and Development Project in Key Fields of Guangdong Province [2020B1111100001]; General Project of Natural Science Foundation of Hunan Province [2022JJ40300]; Scientific Research Project of Hunan Provincial Department of Education [21B0366]

本校为第一且通讯机构

利钠肽（natriuretic peptides， NPs）的发现已有30年历史，其中B型利钠肽（B-type natriuretic peptide， BNP）及氨基末端脑钠肽前体（N-terminal pro-B type natriuretic peptide， NT-proBNP）的临床应用对心血管疾病诊治具有里程碑意义，特别是对心衰的综合价值最高。BNP具备强大的心血管保护效应，但心衰后BNP水平大幅升高，却没展现出相应的活性，被称为“利钠肽悖论”。近几年，随着质谱、核磁共振技术的运用，逐渐从代谢途径和检测技术上解开了“利钠肽悖论”这一谜题：外周循环中存在多种不同生物活性的BNP亚型且心衰后的BNP代谢与生理状态下不同。所以，纵然检测到心衰后BNP大幅升高...

Natriuretic peptides (NPs) have been discovered for 30 years, and the clinical use of B-type natriuretic peptides (BNP) and N-terminal pro-B type natriuretic peptide (NT-proBNP) precursors have been a landmark in the management of cardiovascular disease, particularly in heart failure. The BNP has a powerful cardioprotective effect, but the BNP that rises dramatically after heart failure does not show corresponding activity, which is known as the "natriuretic peptide paradox". In recent years, with the use of mass spectrometry and nuclear magnetic resonance techniques, " natriuretic peptide par...