期刊论文

Efficacy of Colchicine for Patients With Coronary Artery Disease:Meta-analysis and Trial Sequential Analysis

中文

中国循环杂志

1000-3614

2021

36

07

659-666

10.3969/j.issn.1000-3614.2021.07.006

国家自然科学基金面上项目（81973753）；

本校为第一机构

目的:秋水仙碱在冠心病治疗中的作用存在争议,本研究旨在通过Meta分析和试验序贯分析评估秋水仙碱在冠心病患者中预防主要不良心血管事件的效果及安全性。方法:检索中国知网、维普数据库、中国生物医学文献数据库、万方数据库、PubMed、Embase、Cochrane Library、Web of Science数据库,对比较秋水仙碱组和对照组(安慰剂或仅常规处理)冠心病患者主要不良心血管事件发生情况的随机对照研究进行Meta分析和试验序贯分析。结果:共纳入5项随机对照研究、10 923例患者。与对照组相比,秋水仙碱组冠心病患者的主要不良心血管事件发生风险显著降低(RR=0.70,95%CI:0.61~0.80,P

Objectives:The therapeutic role of colchicine in coronary artery disease is controversial.This systematic review evaluated the effect and safety of colchicine in preventing major adverse cardiovascular events.Methods:Eight databases,including CNKI,VIP,CBM,Wanfang,PubMed,Embase,Cochrane Library,Web of Science,were searched.Meta-analysis and trial sequential analysis (TSA) were analyzed on randomized controlled trials (RCTs) comparing the effects of colchicine or placebo/no treatment on major adverse cardiovascular events in patients with coronary artery disease.Results:5 RCTs with a total of 10...