Long non-coding RNA-SRA promotes neointimal hyperplasia and vascular smooth muscle cells proliferation via MEK-ERK-CREB pathway

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成果类型：

期刊论文

作者：

Zhang, Chan-Juan;Liu, Chan;Wang, Yu-Xiang;Zhu, Neng;Hu, Zhe-Yu;...

通讯作者：

Qin, Li

作者机构：

[Liu, Chan; Zhang, Chan-Juan; Liao, Duan-Fang; Wang, Yu-Xiang; Qin, Li] Hunan Univ Chinese Med, Sch Pharm, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

[Zhang, Chan-Juan; Liao, Duan-Fang; Wang, Yu-Xiang; Qin, Li] Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, Changsha, Hunan, Peoples R China.

[Liu, Chan] Liuyang Peoples Hosp, Liuyang, Hunan, Peoples R China.

[Zhu, Neng] Hunan Univ Chinese Med, Affiliated Hosp 1, Changsha, Hunan, Peoples R China.

[Hu, Zhe-Yu] Cent S Univ, Dept Breast Med Oncol, Affiliated Canc Hosp, Xiangya Sch Med, Changsha, Hunan, Peoples R China.

通讯机构：

[Qin, Li] H

Hunan Univ Chinese Med, Sch Pharm, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

Steroid receptor RNA activator;Neointimal hyperplasia;Vascular smooth muscle cell;Proliferation;MEK-ERK-CREB pathway

期刊：

Vascular Pharmacology

ISSN：

1537-1891

年：

2019

卷：

116

页码：

16-23

DOI：

10.1016/j.vph.2019.02.005

基金类别：

National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81270359, 81774130, 81670268]; Hunan traditional Chinese Medicine Administration [201614]; Science Foundation for Distinguished Young Scholars of Hunan ProvinceNational Natural Science Foundation of China (NSFC)National Science Fund for Distinguished Young Scholars [2018JJ1018]; Hunan Provincial Key Discipline of Pharmaceutical Science

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

药学院

摘要：

Long noncoding RNA-steroid receptor RNA activator (LncRNA-SRA) is transcribed from a class of noncoding genes, and plays a critical role in regulating cell proliferation. However, the effect of lncRNA-SRA remains unclear in vascular proliferative diseases. In the present study, we overexpressed lncRNA-SRA in vitro, then investigated the biological consequences. A vascular damage mice model was constructed by performing femoral artery wire injury. LncRNA-SRA was overexpressed in the injured arteries, and significantly promoted the expression of ki67, thereby caused an overall increase in neoint...

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Long non-coding RNA-SRA promotes neointimal hyperplasia and vascular smooth muscle cells proliferation via MEK-ERK-CREB pathway

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