This research work was supported by a grant from the National Natural Science Foundation of China (No. 21275042 ); Hunan Provincial Science and Technology Department (No. 2015JC3072 ).
机构署名：
本校为其他机构
院系归属：
药学院
摘要：
The early detection of bacterium plays a significant role in addressing serious public health issues. In this paper, a supersensitive multichannel series piezoelectric quartz crystal (MSPQC) sensor of bacterium based on 16S rRNA and “DNA-RNA switch” was constructed. The fragment in specific region of 16S rRNA was used as the biomarker of bacterium to ensure high specificity and to achieve the accurate judgment of microbial vitality. “DNA-RNA switch” was designed to conduct two electrodes by switching insulated “gene-link” into conductive ...
